Effects of the changes between preand post-treatment 18F-FDG PET-CT volumetric parameters on overall survival in pleural mesothelioma

Introduction. This study aimed to examine the efficacy of positron emission tomography in fusion with computed (PET-CT) parameters predicting survival outcomes for patients malignant pleural mesothelioma. Material and methods. retrospectively evaluated data 250 who were followed up after a diagnosis The relationship pre-treatment [maximum standardized uptake value (SUVmax1), metabolic tumor volume (MTV1), total lesion glycolysis (TLG1), tumor/background (TBR1), thickness1), post-treatment (SUVmax2, MTV2, TLG2, TBR2, thickness2], DPET-CT was 36 whose pre- CT scan examinations complete. Results. median age 57.5 years, ranging from 35 76. Median follow-up time 16 months, range 7 42 months. calculated as 18.8 months all patients. Based on determined cut-off values, overall 29.9 TLG2 ≤ 158 compared > (p = 0.009) 30.9 DTLG –62.58 0.001). In addition, (OS) MTV2 63.9 0.007) DMTV –54.03 0.002). When respect TBR2; OS TBR2 1.84 0.039). Conclusions. Our research findings indicate correlation between volumetric PET-CT measures, specifically TLG MTV.